Journal of Clinical and Experimental Investigations

Abstract

Objective: Carpal tunnel syndrome (CTS) is formed by the compression of median nerve passes under the level of the transverse carpal ligament at the level of the wrist. CTS is the most common type of entrapment neuropathy. Mostly underlying cause of this entrapment is unknown. Mean platelet volume (MPV), is an important indicator in a positive direction for platelet activation and function. In this study, increased thrombocyte activation due to increased mean thrombocyte volume is whether an important indicator for CTS diagnosis or not was researched.
Methods: In this study, 418 patients diagnosed with CTS and 120 controls were enrolled, including 538 people. In both groups, demographic data, and hemoglobin (HGB), mean corpuscular volume (MCV), red cell distribution width (RDW), platelet count (PLT), MPV, platelet distribution width (PDW) parameters were evaluated.
Results: The mean HGB, MCV values were significantly lower in the CTS group than those of controls(p <0.001). RDW, PDW values were statistically higher in the CTS group (p <0.001). The mean MPV was significantly different between groups (p <0.005). The mean PLT did not reach statistically significant difference between groups (p = 0,484).
Conclusion: The results of our study demonstrated that the increased MPV and PDW values and other related hemogram parameters (HGB, MCV, RDW) may provide useful information in the diagnosis and be predictive in patients with CTS.