Journal of Clinical and Experimental Investigations

Abstract

Objectives: Myocardial dysfunction in patients with hearth failure is suggested to occur due to membrane changes caused by oxidative stress. The aim of this study is to evaluate whether there is a relationship between the degree of hearth failure and oxidative stress, and the effect of hearth failure therapy on oxidative stress parameters.
Materials and methods: We measured enzyme activities of catalase (CAT) and lipid hydroperoxide (LOOH) from blood samples of 67 patients with decompensate hearth failure (pre-treatment group), who have compensated with the treatment (post-treatment group, n=54) according to clinical findings and two-dimensional echocardiography and 47 healthy volunteers (control group).
Results: We found CAT enzyme activities of patients with pre- and post-treatment groups were significantly lower than in control subjects (15.76±2.28 U/L; 17.36±1.55 U/L; 20.50±2.52 U/L, respectively, p<0.0001). LOOH enzyme activities of pretreatment group was also significantly higher than in control group (10.89±3.83 μmol H₂O₂Eqv./L; 6.09±0.85 μmol H₂O₂ Eqv./L respectively, p<0.0001). In the same way, LOOH enzyme activities of posttreatment group was higher than pretreatment group and this was statistically significant (18.77±5.42 μmol H₂O₂Eqv./L; 10.96±3.72 μmol H₂O₂ Eqv./L respectively, p<0.0001).
Conclusion: As a result of our study, oxidative stress increased in patients with decompensated heart failure and compensation treatment also showed increased oxidative stress.