Journal of Clinical and Experimental Investigations

Abstract

Objectives: Although the pathophysiology of tinnitus has not been understood well it is thought to be as a result of anatomical and/or functional change in hearing system. The aim of this study was to compare audiological test results and visual analog scala (VAS) scores after use of trimetazidine hydrocloride in patients with tinnitus.
Materials and methods: Forty patients (12 female, 28 male) who were admitted to our clinic with tinnitus complaint were included in this study. Demographical and medical records and tinnitus assessment data of the cases were recorded who received regular trimetazidine hydrochloride treatment for 3 months. Both pre- and post-treatment values of pure audiograms, frequency and intensity of tinnitus, minimal masking, residual inhibition, and the values in VAS questionnaire form were also evaluated from patient files.
Results: According to the statistical analysis, tinnitus intensity, frequency of tinnitus, discomfort value due to tinnitus and the concentration loss due to tinnitus values in VAS test were found to be decreased after medication (p=0.001). Among the audiological findings of patients, tinnitus frequency (p=0.250), tinnitus intensity (p=0.057), minimal masking level (p= 0.213), and residual inhibition values were found to have no statistically significant changes.
Conclusions: It was found that three-months treatment of trimetazidine treatment caused reduction in tinnitus complaints of patients and did not cause any significant change in audiological test results.