Abstract
Aim: The aim of this study was to investigate the protective effect of myrtus communis extract (MCE) against renal I/R injury.
Materials and methods: 36 adult males Wistar albino rats, weighing 250-300 g, were divided into six groups of six rats each. Group 1 was designated as the sham group. Group 2 was designated as the control one. MCE was administered via gastric gavage over a period of 10 days, dosed at 0.1 mL/kg/day in the third group, 0.2 mL/kg/day in the fourth group, 0.3 mL/kg/day in the fifth group, and 0.5 mL/kg/day in the sixth group. On the 10th day, the I/R procedure was performed.
Results: The pathological examination showed that the formation of hyaline cylinders in the tubular lumen was significantly higher in the control group when compared to the others (p<0.05). Glomerular Bowman space enlargement was statistically significantly lower in groups 5 and 6 compared with the controls (p<0.05). The levels of tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), IL-6, matrix metalloproteinase-8 (MMP-8), hydroxyproline, myeloperoxidase (MPO), and total oxidant status (TOS) were found to be increased in the control group when compared with the others (p<0.05), while a statistically significant reduction was seen in the levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) (p<0.05).
Conclusions: MCE protected kidney tissue against I/R injury. This result was most likely due to the antioxidant properties of MCE. MCE is a promising natural substance for preventing I/R damage.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Type: Research Article
J CLIN EXP INVEST, Volume 13, Issue 4, December 2022, Article No: em00807
https://doi.org/10.29333/jcei/12410
Publication date: 29 Aug 2022
Article Views: 941
Article Downloads: 364
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