Journal of Clinical and Experimental Investigations

Abstract

Inflammatory myofibroblastic tumor is a borderline neoplasm with uncertain malignant potential. The most frequent site of localization is the lungs. The localization in larynx in the head-neck area is rather rare. The 11-year-old female patient had the symptom of hoarse voice, which had been continuing for three years. The laryngoscopy performed showed a polypoid tissue with a wide base, which involved the left vocal cord at full length. The polypoid tissue was completely excised. The histopathological examination performed demonstrated several myofibroblasts with intranuclear pseudo-inclusions, which were surrounded by mixed inflammatory infiltrates in a myxoid stroma. No significant atypia, mitosis and necrosis were observed. The immunochemistry stains were positive for Vimentin, ALK and EMA in neoplastic cells. Alcian blue stain was positive in the myxoid stroma. The case was diagnosed with laryngeal inflammatory myofibroblastic tumor in the light of histopathological and immunohistochemical findings. Laryngeal inflammatory myofibroblastic tumor, a rare entity, should definitely be distinguished from malignant laryngeal tumors. Accurate diagnosis ensures that unnecessary and aggressive treatment methods are avoided and complete, organ-salvaging resection adequate for the inflammatory myofibroblastic tumor be conducted.