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Abstract
Objective: In this study, CD23, low affinity immunoglobulin E receptor, expression in the adenoid tissue was investigated immunohistochemically and evaluated with regard to upper respiratory tract infection complaints and allergy.
Methods: This retrospective study was performed by the selection of 100 patients aged 2-13 years who underwent adenoidectomy/adenotonsillectomy and in whom the adenoid tissue pathological studies were reported as “lymphoid hyperplasia and chronic infection” were evaluated. Immunohistochemical evaluation of CD23 expression was scored semiquantitatively between 0-3 in the tissue samples.
Results: The mean age in the study group was 70.7 months; 46% were female; 30% of patients had adenoidectomy only. Following the operation, the infection frequency decreased in 91% of patients, whereas allergy symptoms were unchanged in 84%. CD23 expression was found significantly lower in patients who had allergic manifestations, namely urticaria (p=0.041), drug sensitivity (p=0.035) and pollen allergy (p=0.037).
Conclusion: A significantly reduced CD23 expression was found in adenoidal tissue in patients with allergic symptoms. These results can be assessed as an underlying mechanism for the recurrence of respiratory tract complaints in these children, despite adenoidectomy.
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Article Type: Research Article
J Clin Exp Invest, Volume 4, Issue 1, March 2013, 1-7
https://doi.org/10.5799/ahinjs.01.2013.01.0225
Publication date: 14 Mar 2013
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